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KMID : 1094020150320050417
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Journal of Veterinary Clinics
2015 Volume.32 No. 5 p.417 ~ p.421
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Evaluation of the Biocompatibility of Cuttlebone in Mouse
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Won Sang-cheol
Lee Joo-Myoung
Cheong Jong-Tae
Park Hyun-Jung
Seo Jong-Pil
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Abstract
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Bone grafting is widely used to bridge major bone defects or to promote bone union. Natural calcium carbonate (CC) has been used as a bone substitute material and used to scaffold for bone morphogenetic protein (BMP). The aims of this study is to evaluate the biocompatibility of cuttlebone (CB) and hydroxyapatite from CB (CBHA). Each material was shaped into disks (5 mm in diameter and 2 mm in thickness). To test biocompatibility, the disks were implanted into the dorsal subcutaneous tissue in mice. Fibrous capsule thickness around each disk was evaluated histologically at 2 and 4 weeks after implantation. Concerning biocompatibility, fibrous capsule thickness of CBHA was significantly thinner than that of CB and CHA (p < 0.05) at 2 and 4 weeks after implantation. Based on the clinical and histological results, CBHA would be a safe material for use inside the body and has more effective osteoconduction than CB.
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KEYWORD
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Bone graft, Cuttlebone (CB), Hydroxyapatite (HA), Scaffold
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